In this chapter we focus on that PAP is acylated to APAP by two-steps synthesis.
4 Production Method Summarization
4.1 Main reaction equation:
4.2 Procedure
This design mainly involves three main steps: acylation, refining and dry. The following is the details.
1) Compounding: Matching of material based on fixed ratio under given condition.
2) Acylation: Acylating raw material matched under given condition.
3) Crystallization: Cooling solution acylated with cool water in cooling pan, then filtrating by centrifuge.
4) Decolorization: Decolorizing for gloss crystal with active carbon, then filtrating.
5) Crystallization.
6) Dry and packing.
4.3 Main equipment control
1) Matching pan: Terminal temperature: 90℃,testing acidity of solution
2) Acylation pan: Terminal temperature: 135℃
3) Cooling crystallizing pan: Terminal temperature: 20℃
4) Decolorizing dissolving pan: Observing the color
5) Fractionating rectifying tower: Neutralization titration controlling peak of the tower acidity≦5%
6) Evaporator: P=0.266kgf/cm2
目录
1 总论 1
1.1 产品用途 1
1.2 产品性能 1
1.2.1 产品介绍 1
1.2.2 理化性质 1
1.2.3 产品质量规格 1
1.2.4 产品包装方式 2
1.3 原料及中间体介绍 2
1.3.1 对氨基苯酚 2
1.3.2 醋酸 2
1.4 国内外市场综述 3
1.5 扑热息痛合成工艺路线设计 3
1.5.1 合成路线概述 3
1.5.2 对乙酰氨基苯酚的二步合成法 3
1.5.3 对乙酰氨基苯酚的一步合成法 8
1.5.4 结论 10
2 工艺流程 11
2.1 主反应化学方程式 11
2.2 工艺流程简述 11
2.3流程框图 13
2.4 带控制点工艺流程图 13
3 物料衡算 14
3.1 物料衡算计算依据 14
3.2 各主要工序的物料衡算 15
3.2.1 生产规模的确定 15
3.2.2 原料投料量的计算 16
3.2.3 酰化 16
3.2.4 冷却结晶 19
3.2.5 溶解脱色 21
3.2.6 精制冷却结晶 22
3.2.7 干燥 24
3.2.8 蒸发器 25
3.2.9 浓缩锅 26
3.2.10 酸母液浓缩后冷却结晶 26
3.2.11 精馏 27
3.2.12 物料衡算图 28
4 化工设备的计算及选型 29
4.1 主要设备计算及选型 29
4.1.1 配料锅 29
4.1.2 酰化锅 29
4.1.3 酰化后冷却结晶锅 30
4.1.4 溶解脱色锅 30
4.1.5 溶解冷却结晶锅 31
4.1.6 酸母液浓缩锅 31
4.1.7 酸母液浓缩后冷却结晶锅 32
4.1.8 精母液冷却结晶锅 32
4.2 辅助设备计算及选型 33
4.2.1 98％浓醋酸储槽 33
4.2.2 酸母液储槽 33
4.2.3 62％稀醋酸储槽 33
4.2.4 85％回收酸储槽 33 扑热息痛生产工艺设计+CAD图纸(3):http://www.youerw.com/yixue/lunwen_8971.html