A variation in NOS1AP gene is associated with repaglinide
A variation in NOS1AP gene is associated with repaglinide
efficacy on insulin resistance in type 2 diabetes of Chinese
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Wen Qin , Rong Zhang , Cheng Hu, Cong-rong Wang, 论文范文http://www.chuibin.com/ Jing-yi Lu, Wei-hui Yu, Yu-qian Bao,本文来自优.文,论-文·网原文请找腾讯324.9114
Kun-san Xiang, The International Type 2 Diabetes 1q Consortium, and Wei-ping Jia
Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong
University Affiliated Sixth People's Hospital, Shanghai 200233, China
Abstract
Aim—A high degree of inter-individual variability response to oral anti-diabetic drug has been
reported. Variations in the neural nitric oxide synthase adaptor protein (NOS1AP) involved in insulin
secretion and insulin signal pathway may explain some of the variability in response to anti-diabetic
drug.
Methods—The study investigated a potential association between SNP rs10494366 in NOS1AP
and efficacy of repaglinide (an insulin secretagogue) in newly diagnosed Shanghai Chinese type 2
diabetes patients. A total of 104 newly diagnosed type 2 diabetes patients (69 men, 35 women) were
recruited and treated with repaglinide for 24 weeks. Anthropometric measurements, clinical
laboratory tests were obtained at baseline and after 24-week treatment. Genotyping was performed
by sequencing.
Results—The baseline value of BMI, HOMA-IR, HOMA-B, and fasting insulin level were
significantly different between GG, GT, and TT genotypes (P = 0.024, 0.030, 0.005, and 0.007,
respectively). Carriers of TT genotype were in significant insulin resistance at baseline. After 24-
week repaglinide monotherapy, the Δ value of fasting insulin (P = 0.019) and HOMA-IR (P = 0.011)
were significantly different. TT carriers had the least insulin resistance after treatment. The mixed
model analysis showed that the variation had an interaction effect with repaglinide treatment only
on HOMA-IR (P = 0.013).
Conclusion—A common variant in rs10494366 is associated with repaglinide monotherapy
efficacy on insulin resistance in newly diagnosed Shanghai Chinese type 2 diabetes patients.
Keywords
pharmacogenetics; repaglinide; single nucleotide polymorphisms; insulin resistance; nitric oxide
synthase 1 (neuronal) adaptor protein; NOS1AP2494